Benefit and risk of intrathecal morphine without local anaesthetics in patients undergoing major surgery. Meta-analysis of randomised trials. (Br J Anaesth 2009; 102:156-67)
Meylan N, Elia N, Lysakowski C, Tramèr M R
Flow chart
Relation between year of publication and dose of intrathecal morphine
Extubation delay
Duration of hospital stay
Drug consumption:
Perioperative opioid requirements
24h morphine consumption
24h to 48h Morphine consumption
Pain measurments:
Pain intensity at rest at 2h
Pain intensity at rest at 4h
Pain intensity at rest at 12h
Pain intensity at rest at 24h
Pain intensity on movement at 12h
Pain intensity on movement at 24h
Adverse effects:
Nausea, Vomiting
Any pruritus, Pruritus needing treatment
Sedation
Respiratory depression
Pulmonary complications
Urinary retention
Clonidine as an Adjuvant to Intrathecal Local Anesthetics for Surgery. Systematic Review of Randomized Trials. (Regional Anesthesia and Pain Medicine 2008; 33(2):159-67)
Elia N, Culebras X, Mazza C, Schiffer E, Tramèr M R
Included RCTs
The statistical model
Additional figures:
Time to regression to L2
Time to complete sensory block
Extent of cephalic spread of sensory block
Time to complete motor block
Intra-operative pain
Intra-operative hypotension
Intra-operative bradycardia
Additional figures (weight adjusted doses):
Figure 2
Figure 3
Figure 4
Time to regression to L2
Time to complete sensory block
Extent of cephalic spread of sensory block
Time to complete motor block
Intra-operative pain
Intra-operative hypotension
Intra-operative bradycardia
Impact of the Intubation Model on the Efficacy of Rocuronium during Rapid Sequence Intubation: Systematic Review of Randomised Trials (Acta Anaesthesiologica Scandinavica, 2007; 51: 848-857)
Lysakowski C, Suppan L, Tassonyi E, Czarnetzki C, Tramèr MR
Analysed randomised controlled trials
Table 1: Randomized controlled trials of true rapid sequence intubation
Table 2: Randomized controlled trials of modified rapid sequence intubation
Prevention of Succinylcholine-induced Fasciculation and Myalgia:
A Meta-analysis of Randomized Trials (Anesthesiology, 2005; 103:877-84)
Schreiber JU, Lysakowski C, Fuchs-Buder T, Tramèr MR
Analysed trials
A-L, M-Z
Fasciculation (individual meta-analyses)
Fasciculation
Myalgia (individual meta-analyses)
Myalgia
Does Multimodal Analgesia with Acetaminophen, Nonsteroidal Antiinflammatory Drugs or Selective Cyclooxygenase-2 Inhibitors and Patient-controlled Analgesia Morphine Offer advantages Over Morphine Alone? Meta-analyses of Randomized Trials (Anesthesiology, 2005; 103:1296-1304)
Elia N, Lysakowski C, Tramèr MR
Analysed trials
Acetaminophen, COX-2, NSAID
Table
Regimens tested
Detailed meta-analyses
Morphine sparing
Acetaminophen, COX-2, NSAID
VAS pain intensity
Acetaminophen, NSAID
Morphine-related adverse effects
Acetaminophen, COX-2, NSAID
Drug-related adverse effects
COX-2, NSAID
Individual trial data
Morphine-related adverse-effects
Respiratory depression
Nausea
Vomiting
Nausea or vomiting
Urinary retention
Pruritus
Dizziness
Sedation
Bowel dysfunction
Drug-related adverse effects
Gastro-intestinal bleeding
Oliguria
Renal failure
Surgical bleeding
Ketamine and postoperative pain: A quantitative systematic review of randomised trials (Pain 2005, 113:61-70)
Elia N, Tramèr M R
Analysed trials
Prophylactic iv. ketamine in adults
Ketamine added to an opioid in an iv. PCA device
Prophylactic epidural ketamine in adults
Therapeutic epidural ketamine in adults
Prolonged (>24 hours) iv. ketamine in adults
Iv. ketamine in sedated adults
Prophylactic intravenous ketamine in children
Prophylactic caudal ketamine in children
Other ketamine regimen
Figures
Flow chart
VAS of pain intensity
Cumulative morphine consumption
Opioid-related adverse effects
Time to first request of analgesic
Risk of hallucinations according to the weight adjusted ketamine dose
Is low-dose haloperidol a useful antiemetic? A meta-analysis of published and unpublished randomized trials (Anesthesiology 2004;101:1454-1463)
Büttner M, Walder B, Von Elm E, and Tramèr M R
Haloperidol as an antiemetic in chemo- and radiotherapy
Analysed trials
McNeil report: Haldol (haloperidol) injection injection for use as an antiemetic agent, McNeil Laboratories Inc. January, 1974
Introduction (part I; p. 1-2)
Phase II clinical evaluation (part II; p. 4-11)
Phase III clinical evaluation (postoperative use) (part IIIa; p. 13-39 and 40-49)
Phase III clinical evaluation (gastrointestinal use) (part IIIb; p. 50-76 and 77-91)
Summary and conclusions, supporting information, appendix, references (part IV-VII; p. 93-99)
Efficacy and harm of pharmacological prevention of acute mountain sickness: quantitative systematic review (BMJ 2000;321:267-272)
Dumont L, Mardirosoff C, Tramèr M R
Analysed trials
